Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression
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چکیده
منابع مشابه
Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin
Despite being an invaluable chemotherapeutic agent for several types of cancer, the clinical utility of doxorubicin is hampered by its age-related and dose-dependent cardiotoxicity. Co-administration of dexrazoxane as a cardioprotective agent has been proposed, however recent studies suggest that it attenuates doxorubicin-induced antitumor activity. Since compounds of natural origin present a r...
متن کاملCytotoxicity of the beta-carboline alkaloids harmine and harmaline in human cell assays in vitro.
beta-Carboline alkaloids are natural products widely distributed in plants and also found in alcoholic beverages, well-cooked foods and tobacco smoke. Various authors have reported genotoxic activities of several carboline in prokaryotic and eukaryotic cells that have been attributed to their abilities to intercalate into DNA. But studies on the genotoxic and on the cytotoxic potencies in human...
متن کاملHarmine is a β-carboline alkaloid present at highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants
Harmine is a β-carboline alkaloid present at highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell...
متن کاملAnti-prostate cancer activity of a beta-carboline alkaloid enriched extract from Rauwolfia vomitoria.
The tropical shrub, Rauwolfia vomitoria, is a medicinal plant used traditionally to treat a variety of ailments. A bioactive beta-carboline alkaloid, alstonine, present in this extract was previously shown to have anti-cancer activity against cancer cell lines. This study considers the potential anti-prostate cancer activity of this extract in vitro and in vivo. Rauwolfia vomitoria extract stan...
متن کاملData in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis
A harmine-derived beta-carboline, CM16, inhibits cancer cells growth through its effects on protein synthesis, as described in "A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis" (Carvalho et al., 2017)[1]. This data article provides accompanying data on CM16 cytostatic evaluation in cancer cells as well as data related to its effects on trans...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2011
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2010.10.016